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Inventi Impact: Oncology

Articles

  • Inventi:hoc/31716/20
    Impact of Double J Stenting or Nephrostomy Placement During Transurethral Resection of Bladder Tumour on the Incidence of Metachronous Upper Urinary Tract Urothelial Cancer
    Research 2020 : July - September
    Marie C Hupe, Lukas Dormayer, Tomasz Ozimek, Julian P Struck, Martin J P Hennig, Melanie Klee, Christoph A J von Klot, Markus A Kuczyk, Axel S Merseburger, Mario W Kramer

    Background: Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT)\nharms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development\nremains controversial. This study evaluated the impact of DJ compared to nephrostomy placement during TURBT\nfor bladder cancer (BCa) on the incidence of metachronous UUTUCs.\nMethods: We retrospectively analysed 637 patients who underwent TURBT in our department between 2008 and\n2016. BCa, UUTUC and urinary drainage data (retrograde/anterograde DJ and percutaneous nephrostomy) were\nassessed, along with the prevalence of hydronephrosis, and mortality. Chi-square and Fisherâ??s exact test was\nperformed for univariate analyses. Survival analysis was performed by the Kaplan-Meier method and log-rank tests.\nResults: UUTUC was noted in 28 out of 637 patients (4.4%), whereas only eight (1.3%) developed it\nmetachronously to BCa. Out of these, four patients received DJ stents, while four patients received no urinary\ndrainage of the upper urinary tract. Placement of urinary drainage significantly correlated with UUTUC (50.0% vs.\n17.9%; p = 0.041). DJ stenting significantly correlated with UUTUC (50.0% vs. 11%; p < 0.01), while no patient with a\nnephrostomy tube developed UUTUC. UUTUC-free survival rates were significantly lower for patients with DJ stents\nthan for all other patients (p = 0.001). Patients with or without DJ stents had similar overall survival (OS) rates (p =\n0.73), whereas patients with nephrostomy tubes had significantly lower OS rates than all other patients (p < 0.001).\nConclusions: Patients with DJ stenting during TURBT for BCa might have an increased risk of developing\nmetachronous UUTUC. This study indicated advantages in placing nephrostomy tubes rather than DJ stents;\nhowever, confirmation requires investigation of a larger cohort. Even so, the increased mortality rate in the\nnephrostomy group reflected hydronephrosis as an unfavourable prognostic factor.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Hupe, Marie C., et al.\n\"Impact of double J stenting or nephrostomy placement\nduring transurethral resection of bladder tumour on the\nincidence of metachronous upper urinary tract urothelial\ncancer.\" BMC cancer 20.1 (2020): 1-11.\nhttps://doi.org/10.1186/s12885-020-6620-2\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and\npagination were modified while adapting this article.
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